Thio-ProTide Strategy: a Novel H2S Donor–drug Conjugate (DDC) Alleviates Hepatic Injury Via Innate Lysosomal Targeting

Haowen Jin, Jie Ma, Bixin Xu, Sitao Xu, Tianyu Hu,Xin Jin, Jiankun Wang,Guangji Wang,Le Zhen

Acta Pharmaceutica Sinica B（2024）

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关键词

ProTide prodrug,Hydrogen sulfide donor,Drug conjugate,Cellular pharmacokinetics,Liver fibrosis,Lipid peroxidation,Lysosomal targeting,Prodrug activation

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