Nitrosamine Mitigation: NDMA Impurity Formation and Its Inhibition in Metformin Hydrochloride Tablets

Diaa Shakleya,Alaadin Alayoubi, Dustin Brown, Alaa Mokbel,Nicolas Abrigo, Adil Mohammad,Jiang Wang, David Li, Maha Shaklah, Fahd M. Alsharif, Saaniya Desai, Martha Essandoh, Patrick J. Faustino,Muhammad Ashraf,Thomas O'Connor, Matthew Vera, Andre Raw, Vilayat A. Sayeed,David Keire

INTERNATIONAL JOURNAL OF PHARMACEUTICS（2024）

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Key words

Mitigation,Metformin hydrochloride,NDMA,Stability,Antioxidants,Nitrosamines,N-Nitrosation

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