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Uncovering Mediational Pathways Behind Racial and Socioeconomic Disparities in Brain Volumes: Insights from the UK Biobank Study

May A. Beydoun, Hind A. Beydoun, Marie T. Fanelli-Kuczmarski,Yi-Han Hu,Danielle Shaked, Jordan Weiss,Shari R. Waldstein,Lenore J. Launer,Michele K. Evans,Alan B. Zonderman

GeroScience（2024）

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Abstract
Mediation pathways explaining racial/ethnic and socioeconomic (SES) disparities in structural MRI markers of brain health remain underexplored. We examined racial/ethnic and SES disparities in sMRI markers and tested total, direct, and indirect effects through lifestyle, health-related, and cognition factors using a structural equations modeling approach among 36,184 UK Biobank participants aged 40–70 years at baseline assessment (47
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Key words
Brain aging,Health disparities,Socioeconomic status,Lifestyle factors,Neurodegeneration
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