FcRn-enhancing Mutations Lead to Increased and Prolonged Levels of the HIV CCR5-blocking Monoclonal Antibody Leronlimab in the Fetuses and Newborns of Pregnant Rhesus Macaques

Joanna Zikos,Gabriela M. Webb,Helen L. Wu,Jason S. Reed,Jennifer Watanabe,Jodie L. Usachenko,Ala M. Shaqra,Celia A. Schiffer, Koen K. A. Van Rompay, Jonah B. Sacha,Diogo M. Magnani

MABS（2024）

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Key words

Antibody optimization,entry inhibitor,HIV,leronlimab,Mother-to-child transmission (MTCT),nonhuman primate,rhesus macaque,transplacental antibody transfer

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