The Relationship Between the No-Reflow Phenomenon and the Systemic Immune-Inflammation Index in Saphenous Vein Graft Interventions

Aim: In our retrospective study, we examined patients who underwent percutaneous intervention (PCI) for ischemia involving saphenous vein grafts (SVG). Our objective was to analyze the impact of inflammation and thrombotic events on the no-reflow phenomenon (NRP) post-intervention. For this purpose, we aimed to determine whether the Systemic Immune-Inflammation Index (SII) is a risk factor for the NRP. Patients were divided into two groups based on the occurrence of NRP, and we investigated whether there was a statistically significant difference in SII between the groups. Materials and Methods: This retrospective study included 30 patients who had previously undergone surgical revascularization and underwent PCI on SVG due to ischemia between May 4, 2023, and July 31, 2024. Post-procedural blood flow was evaluated, and patients were divided into two groups based on the development of NRP. The relationship between NRP and SII was examined. Results: The study demonstrated that patients who experienced the NRP had significantly higher SII levels. Additionally, the duration of the procedure was significantly longer in patients with no-reflow. Systemic risk factors, such as age, gender, and comorbidities, were similar between the no-reflow and normal flow groups. Conclusion: This study indicates that inflammation plays a key role in determining flow outcomes following PCI. Further clinical studies focused on reducing inflammation and improving flow are needed.