Association of Human Whole-blood NAD Plus Plus Levels with Nabothian Cyst

Objective Little is known about the association between whole-blood nicotinamide adenine dinucleotide (NAD+) + ) levels and nabothian cysts. This study aimed to assess the association between NAD+ + levels and nabothian cysts in healthy Chinese women. Methods Multivariate logistic regression analysis was performed to analyze the association between NAD+ + levels and nabothian cysts. Results The mean age was 43.0 +/- 11.5 years, and the mean level of NAD+ + was 31.3 +/- 5.3 mu mol/L. Nabothian cysts occurred in 184 (27.7%) participants, with single and multiple cysts in 100 (15.0%) and 84 (12.6%) participants, respectively. The total nabothian cyst prevalence gradually decreased from 37.4% to 21.6% from Q1 to Q4 of NAD+ + and the prevalence of single and multiple nabothian cysts also decreased across the NAD+ + quartiles. As compared with the highest NAD+ + quartile (>= 34.4 mu mol/L), the adjusted odds ratios with 95% confidence interval of the NAD+Q1 + Q1 was 1.89 (1.14-3.14) for total nabothian cysts. The risk of total and single nabothian cysts linearly decreased with increasing NAD+ + levels, while the risk of multiple nabothian cysts decreased more rapidly at NAD+ + levels of 28.0 to 35.0 mu mol/L. Conclusion: Low NAD+ + levels were associated with an increased risk of total and multiple nabothian cysts.