Severity Patterns in COVID-19 Hospitalised Patients in Spain: I-MOVE-COVID-19 Study

Miriam Latorre-Millan, Maria Mar Rodriguez del Aguila,Laura Clusa,Clara Mazagatos,Amparo Larrauri, Maria Amelia Fernandez,Antonio Rezusta, Ana Maria Milagro

VIRUSES-BASEL（2024）

Hosp Univ Virgen Nieves | Carlos III Hlth Inst

Cited 0|Views1

Abstract

In the frame of the I-MOVE-COVID-19 project, a cohort of 2050 patients admitted in two Spanish reference hospitals between March 2020 and December 2021 was selected and a range of clinical factor data were collected at admission to assess their impact on the risk COVID-19 severity outcomes through a multivariate adjusted analysis and nomograms. The need for ventilation and intensive care unit (ICU) admission were found to be directly associated with a higher death risk (OR 6.9 and 3.2, respectively). The clinical predictors of death were the need for ventilation and ICU, advanced age, neuromuscular disorders, thrombocytopenia, hypoalbuminemia, dementia, cancer, elevated creatin phosphokinase (CPK), and neutrophilia (OR between 1.8 and 3.5), whilst the presence of vomiting, sore throat, and cough diminished the risk of death (OR 0.5, 0.2, and 0.1, respectively). Admission to ICU was predicted by the need for ventilation, abdominal pain, and elevated lactate dehydrogenase (LDH) (OR 371.0, 3.6, and 2.2, respectively) as risk factors; otherwise, it was prevented by advanced age (OR 0.5). In turn, the need for ventilation was predicted by low oxygen saturation, elevated LDH and CPK, diabetes, neutrophilia, obesity, and elevated GGT (OR between 1.7 and 5.2), whilst it was prevented by hypertension (OR 0.5). These findings could enhance patient management and strategic interventions to combat COVID-19.

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Key words

COVID-19,SARS-CoV-2,severity,death,ventilation,ICU,clinical phenotype

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【要点】：该研究通过I-MOVE-COVID-19项目，分析了西班牙两家医院2050名COVID-19住院患者的临床因素，提出了预测疾病严重程度及死亡风险的模型，发现需氧疗和ICU入住与死亡风险密切相关。

【方法】：研究采用回顾性队列研究方法，通过多变量调整分析和诺模图，评估了入院时各项临床因素对COVID-19严重程度结果的影响。

【实验】：研究收集了2020年3月至2021年12月间两家西班牙参考医院的2050名住院患者的数据，通过分析得出需氧疗和ICU入住与死亡风险的正相关性（OR分别为6.9和3.2），并确定了其他与死亡风险相关的临床预测因子，以及入住ICU和需氧疗的风险因素。