Probing the Binding and Antiparasitic Efficacy of Azobenzene G-quadruplex Ligands to Investigate G4 Ligand Design Principles

Javier Ramos-Soriano, Maisie Holbrow-Wilshaw, Eliza Hunt,Y Jennifer Jiang,Pablo Peñalver, Juan C Morales, M Carmen Galan

Chemical communications (Cambridge, England)（2024）

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摘要

Novel strategies against parasitic infections are of great importance. Here we describe a G4 DNA ligand with subnanomolar antiparasitic activity against T. brucei and a remarkable selectivity index (IC50 MRC-5/T....

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