Enhanced Platelet Function Through CAR-T Cell Therapy in Relapsed/refractory Multiple Myeloma

Ruixue Ma, Qi Zhang,Yang Liu,Hujun Li,Huimin Chen, Qianqian Zhang,Jianlin Qiao,Kunming Qi, Guifang Shen,Cai Sun,Xuguang Song, Jiang Cao,Hai Cheng,Feng Zhu, Zhiling Yan,Wei Sang,Depeng Li,Haiying Sun,Junnian Zheng,Zhenyu Li,Kailin Xu,Wei Chen

Clinical and experimental medicine（2024）

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摘要

The influence of chimeric antigen receptor T (CAR-T) cell therapy on platelet function in relapsed/refractory (R/R) multiple myeloma (MM) has not been thoroughly investigated. Our cohort comprised fifty MM patients treated with CAR-T cells. The mean platelet closure time (PCT) induced by collagen/adenosine diphosphate (CADP) in peripheral blood was significantly prolonged before lymphodepletion (195.24 ± 11.740 s) and notably reduced post-CAR-T cell therapy (128.02 ± 5.60 s), with a statistically significant improvement (67.22, 95

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关键词

Relapsed/refractory,Multiple myeloma,Chimeric antigen receptor T cell,Platelet function,Prognosis

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