Backpacked Neutrophils Via Noncovalent Interactions: A Candidate for Nova Cell Therapy

Cells, as the fundamental units of life, possess unique and essential functionalities. To harness their full potential and modulate specific phenotypes for challenging diseases treatment, engineered cells have emerged as a promising clinical approach. A recent study published in Nature Biomedical Engineering demonstrates a strategy to engineer drug-free “cell backpacks” onto neutrophil surfaces using bioorthogonal techniques. This innovation enables sustained activation of neutrophils into an anticancer phenotype, facilitating systemic immune regulation for tumor suppression.