2H-Thiazolo[4,5-d][1,2,3]triazole: Synthesis, Functionalization, and Application in Scaffold-Hopping

Ryuya Miyazaki, Fumito Takada, Takunari Kikuchi,Yuya Oguro,Makoto Kamata, Takafumi Yukawa,Kenta Kato,Kei Muto,Junichiro Yamaguchi

Chemical science（2024）

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摘要

This manuscript unveils the synthesis of 2H-thiazolo[4,5-d][1,2,3]triazole (ThTz), an unprecedented [5-5]-fused heteroaromatic system, and established a scalable synthetic procedure for producing large quantities of ThTz ring bearing a sulfone group...

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