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Table S1 from Blockade of IL1β and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor

crossref(2024)

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Abstract
Supplemental Table 1: Selected Adverse Events reported in ≥5 subjects (any grade) or ≥3 subjects for Grade 3 from patients in SR-1. Select immune-related adverse events are also shown.
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要点】:本文探讨了IL1β和PD1联合阻断与化疗结合在转移性胰腺癌中对系统性髓系抑制的影响,并观察到肿瘤中的异质性效应。

方法】:研究采用免疫组化和流式细胞术分析肿瘤微环境,评估治疗对髓系抑制的影响。

实验】:实验在SR-1患者队列中进行,使用的数据集为补充表1中报告的≥5名患者(任何级别)或≥3名3级患者的选定不良事件,以及选定的免疫相关不良事件。结果显示,该治疗方法能够减少系统性髓系抑制,但对肿瘤的影响存在异质性。