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Identification of a Novel 10-Hydroxyevodiamine Prodrug As a Potent Topoisomerase Inhibitor with Improved Aqueous Solubility for Treatment of Hepatocellular Carcinoma

Xiuzhen Wei, Xi Zhang, Yan Peng, Junbo Wu, Hanxuan Mo, Zhigang An, Xinyu Deng,Ying Peng,Linyi Liu,Weifan Jiang,Jinjin Chen,Zecheng Hu,Zhen Wang,Linsheng Zhuo

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY（2024）

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关键词
Evodiamine,Topoisomerases,Aqueous solubility,Quaternary ammonium salt
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