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Organization of Conceptual Tool Knowledge Following Left and Right Brain Lesions: Evidence from Neuropsychological Dissociations and Multivariate Disconnectome Symptom Mapping

Mathieu Lesourd, Julie Martin, Sebastien Hague, Margolise Laroze,Gautier Clement, Alexandre Comte,Elisabeth Medeiros de Bustos, Guillaume Fargeix,Eloi Magnin, Thierry Moulin

Brain and cognition(2024)

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摘要
The aim of this work was to better understand the organization of conceptual tool knowledge following stroke. We explored specifically the link between manipulation kinematics and manipulation hand posture; and the link between manipulation kinematics and function relations in left brain-damaged (n = 30) and right brain-damaged (n = 30) patients. We examined the performance of brain-damaged patients in conceptual tool tasks using neuropsychological dissociations and disconnectome symptom mapping. Our results suggest that manipulation kinematics is more impaired than function relations, following left or right brain lesions. We also observed that manipulation kinematics and manipulation hand posture are dissociable dimensions but are still highly interrelated, particularly in left brain-damaged patients. We also found that the corpus callosum and bilateral superior longitudinal fasciculus are involved in action and semantic tool knowledge following left brain lesions. Our results provide evidence that the right hemisphere contains conceptual tool representations. Further studies are needed to better understand the mechanisms supporting the cognitive recovery of conceptual tool knowledge. An emerging hypothesis is that the right hemisphere may support functional recovery through interhemispheric transfer following a left hemisphere stroke.
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关键词
Conceptual tool knowledge,Action tool knowledge,Semantic tool knowledge,Brain-damaged patients,Neuropsychological dissociations,Disconnectome symptom mapping
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