Efficacy of Non-Invasive Chromosome Screening, Preimplantation Genetic Testing for Aneuploidy, and Morphological Grading in Selecting Embryos of Patients with Advanced Maternal Age: a Three-Armed Prospective Cohort Study

Non-invasive chromosome screening (NICS) and trophectoderm biopsy preimplantation genetic testing for aneuploidy (TE-PGT) were both applied for embryo ploidy detection, However, the cumulative live birth rates (CLBR) of NICS and TE-PGT in older age groups have yet to be reported. This study aimed to ascertain whether NICS and TE-PGT could enhance the cumulative live birth rates among patients of advanced maternal age. A total of 384 couples aged 35–40 years were recruited. The patients were assigned to three groups: NICS, TE-PGT, and intracytoplasmic sperm injection (ICSI). All patients received frozen single blastocyst transfer. Patients in the NICS and TE-PGT groups underwent aneuploidy screening. When compared to the ICSI group, the CLBR was significantly higher in the NICS and TE-PGT groups (27.9