Overwriting an instinct: visual cortex instructs learning to suppress fear responses

Fast instinctive responses to environmental stimuli can be crucial for survival, but are not always optimal. Based on prior experience, animals can thus adapt their behavior and suppress instinctive reactions. However, the neural pathways mediating such ethologically relevant forms of learning remain unclear. We show that posterolateral higher visual areas (plHVAs) are crucial for learning to suppress escapes from innate visual threats through a top-down pathway involving the ventrolateral geniculate nucleus (vLGN). plHVAs are no longer necessary after learning: instead, the learnt behavior relies on plasticity within vLGN populations that exert inhibitory control over fear responses. vLGN neurons receiving input from plHVAs enhance their responses to visual threat stimuli during learning through endocannabinoid-mediated long-term suppression of their inhibitory inputs. We thus reveal the detailed circuit, cellular and synaptic mechanisms underlying experience-dependent suppression of fear responses through a novel corticofugal pathway. ### Competing Interest Statement The authors have declared no competing interest.