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Radiopharmaceutical-Activated Silicon Naphthalocyanine Nanoparticles Towards Tumor Photodynamic Therapy

Tingting Wang,Jingchao Li,Xun Zhang, Chengao Li,Jiang Ming,Jian Li, Dongsheng Zhang,Jun Yang,Nian Liu,Xinhui Su

CHEMICAL COMMUNICATIONS（2024）

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Abstract
Naphthalocyanine-based agents exhibit huge potential in photodynamic therapy, yet their photodynamic performance is restricted by the penetration depth of the external laser. Herein, we employed 18F-FDG as an internal light source to excite silicon naphthalocyanine nanoparticles to simultaneously circumvent radiative transition and boost 1O2 generation for tumor suppression.
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