Antidiabetic and Antioxidant activities of Indian Bay Leaf (Cinnamomum tamala (Buch.-Ham.) T. Nees & Eberm.) Essential Oils Collected from Meghalaya.

The current work investigates the chemodiversity, in vitro antioxidant, α-amylase and α-glucosidase inhibitory potential of Cinnamomum tamala leaf essential oil collected from different localities of East Khasi Hills District of Meghalaya, India. Gas chromatography-mass spectrometry (GC-MS) analysis of all the extracted leaf essential oils facilitated the identification of several compounds in a variable range along with eugenol as the major component (74.79-95.12 %). CT8 exhibited the highest antioxidant activity (IC50 = 11.23 ± 0.27 μg/mL for DPPH and IC50 = 21.54 ± 0.37 μg/mL for ABTS) among all the evaluated EO compounds. The results showed that the FRAP and ORAC values for CT8 were 83.26 ± 1.92 µM trolox/g oil and 70.29 ± 1.90 ascorbic acid equivalents (AAE)/g of oil. α-amylase and α-glucosidase inhibition were highest in sample CT8 with IC50 values of 3.62 ± 0.42 µg/mL and 16.29 ± 0.32 µg/mL respectively. Caryophyllene, cyclohexene, 1, 5, 5-trimethyl-6-(2-propenylidene), germacrene D and eugenol showed strong binding potential toward α-amylase and α-glucosidase.  It concluded that the chemodiversity and antidiabetic potential of C. tamla oil from Khasi Hills have never been studied. It can be taken as a dietary supplement as an antioxidant and antidiabetic to control blood glucose.