Loss of the Tumour Suppressor LKB1/STK11 Uncovers a Leptin-Mediated Sensitivity Mechanism to Mitochondrial Uncouplers for Targeted Cancer Therapy

Andriani Angelopoulou, Giorgos Theocharous,Dimitrios Valakos,Aikaterini Polyzou,Sophia Magkouta,Vassilios Myrianthopoulos,Sophia Havaki,Marco Fiorillo,Ioanna Tremi, Konstantinos Vachlas, Theodoros Nisotakis,Dimitris-Foivos Thanos,Anastasia Pantazaki,Dimitris Kletsas,Jiri Bartek,Russell Petty,Dimitris Thanos, Rory J McCrimmon,Angelos Papaspyropoulos,Vassilis G Gorgoulis

Molecular Cancer（2024）

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Non-small cell lung cancer (NSCLC),LKB1/STK11,HIF1A-LEP-UCP2 axis,Zebrafish,Metabolic stress,Piceatannol,Tyrphostin 23,Airway organoids,CRISPR/Cas9-mediated genome editing,Drug discovery

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