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BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome

Petra Gorombei,Fabien Guidez,Saravanan Ganesan,Mathieu Chiquet,Andrea Pellagatti,Laure Goursaud,Nilgun Tekin,Stephanie Beurlet,Satyananda Patel,Laura Guerenne,Carole Le Pogam,Niclas Setterblad,Pierre de la Grange,Christophe LeBoeuf,Anne Janin,Maria-Elena Noguera,Laure Sarda-Mantel,Pascale Merlet,Jacqueline Boultwood,Marina Konopleva,Michael Andreeff,Robert West,Marika Pla,Lionel Adès,Pierre Fenaux,Patricia Krief,Christine Chomienne,Nader Omidvar,Rose Ann Padua

International Journal of Molecular Sciences（2021）

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关键词
HR-MDS,BCL-2,ABT-737,gene regulation
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