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Anion-Exchange Chromatography at the Service of Gene Therapy: Baseline Separation of Full/Empty Adeno-Associated Virus Capsids by Screening of Conditions and Step Gradient Elution Mode

Megane K. Aebischer,Hugo Gizardin-Fredon,Honorine Lardeux,Dominik Kochardt,Carsten Elger,Markus Haindl,Raphael Ruppert,Davy Guillarme,Valentina D’Atri

International Journal of Molecular Sciences（2022）

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Key words
anion-exchange chromatography,step gradient,gene therapy,recombinant adeno-associated virus,full/empty ratio
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