Graphene-modified electrochemical analysis system for the detection of food-borne stimulants sibutramine in sports

A novel graphene-modified molecularly imprinted polymer-based electrochemical sensor (MIP/RGO-GCE) was developed for the sensitive and selective detection of sibutramine in sports doping control. The sensor was fabricated by electropolymerizing o-phenylenediamine on a reduced graphene oxide-modified glassy carbon electrode in the presence of sibutramine as the template molecule. Under optimized conditions, the MIP/RGO-GCE sensor exhibited a wide linear range (0.05 to 20 μM), low detection limit (0.02 μM), high sensitivity (1.27 μA/μM), good precision (RSD < 2.7