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Adjuvant Systemic Therapy Improved Survival after Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma

Francesco Di Bello,Letizia Maria Ippolita Jannello,Carolin Siech,Mario de Angelis,Natali Rodriguez Peñaranda,Zhe Tian,Jordan A. Goyal,Claudia Collà Ruvolo,Gianluigi Califano,Massimiliano Creta,Simone Morra,Fred Saad,Shahrokh F. Shariat,Ottavio de Cobelli,Alberto Briganti,Felix K. H. Chun,Stefano Puliatti,Nicola Longo,Pierre I. Karakiewicz

ANNALS OF SURGICAL ONCOLOGY（2024）

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Abstract
The purpose of this study was to test for survival differences according to adjuvant chemotherapy (AC) status in radical nephroureterectomy (RNU) patients with pT2–T4 and/or N1–2 upper tract urothelial carcinoma (UTUC). Within the Surveillance, Epidemiology, and End Results database (SEER, 2007–2020), patients with UTUC treated with AC versus RNU alone were identified. Kaplan–Meier plots and multivariable Cox regression models addressed cancer-specific mortality (CSM). Of 1995 patients with UTUC, 804 (40
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Key words
Systemic therapy,UTUC,SEER,Disease-free survival
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