Development of non-invasive diagnosis based on FTIR spectroscopy

Numerous illnesses progress silently, often reaching a critical stage by the time symptoms appear, making medical intervention difficult. While there exist sophisticated clinical techniques for precise disease detection, they are often invasive procedure and as a rule of thumb is used only with definite symptomatic cases. In addition, the extreme clinical costs prevent a large population from taking advantage of contemporary medical facilities. A non-invasive, economically feasible screening method that detects diseases even in their presymptomatic stages may overcome many critical challenges in health and medicine. Utilizing vibrational spectroscopy to identify volatile metabolites offers promise as such a non-invasive, cost-effective diagnostic tool. The article outlines the potential of vibrational spectroscopy for non-invasive diagnostics and proposes a method for its clinical implementation.