Design of Soluble HIV-1 Envelope Trimers Free of Covalent Gp120-Gp41 Bonds with Prevalent Native-Like Conformation

Peng Zhang,Jason Gorman,Yaroslav Tsybovsky,Maolin Lu,Qingbo Liu,Vinay Gopan, Mamta Singh,Yin Lin,Huiyi Miao, Yuna Seo,Alice Kwon,Adam S. Olia,Gwo-Yu Chuang,Hui Geng, Yen-Ting Lai,Tongqing Zhou,John R. Mascola,Walther Mothes,Peter D. Kwong,Paolo Lusso

Cell Reports（2024）

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关键词
HIV-1,envelope,soluble trimer,native structure,stabilization,CD4 binding,structure-guided design,cryo-EM,neutralizing antibodies,vaccine immunogen
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