Is Trofinetide a Future Treatment for Rett Syndrome? A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Trials
BMC MEDICINE(2024)
Abstract
Rett syndrome (RTT) is a rare, life-threatening, genetic neurodevelopmental disorder. Treatment in RTT encounters many challenges. Trofinetide, a modified amino-terminal tripeptide of insulin-like growth factor 1, has demonstrated clinically promising results in RTT. In this study, trofinetide efficacy and safety in RTT are systematically reviewed and meta-analyzed. A systematic search of five electronic databases was conducted until January 2024. Review Manager 5.4 software was used for the analysis. The analysis was based on a weighted mean difference and standard error with a confidence interval (CI) of 95
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Key words
Rett syndrome,RTT,Trofinetide,Neurodevelopmental disorders,Systematic review,Meta-analysis
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