Desmopressin for Prevention of Bleeding for Thrombocytopenic, Critically Ill Patients Undergoing Invasive Procedures: A Randomised, Double-Blind, Placebo-Controlled Feasibility Trial
EJHAEM(2024)
摘要
Thrombocytopenic patients have an increased risk of bleeding when undergoing invasive procedures. In a multicentre, phase II, blinded, randomised, controlled feasibility trial, critically ill patients with platelet count 100 x 109/L or less were randomised 1:1 to intravenous desmopressin (0.3 mu g/kg) or placebo before an invasive procedure. Forty-three participants (18.8% of those eligible) were recruited, with 41 eligible for analysis. Post-procedure bleeding occurred in one of 22 (4.5%) in the placebo arm and zero of 19 in the desmopressin arm. Despite liberal inclusion criteria, there were significant feasibility challenges recruiting patients in the critical care setting prior to invasive procedures.
更多查看译文
关键词
bleeding disorders,desmopressin,thrombocytopenia
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要