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Synthetic Lethal CRISPR Screen Identifies a Cancer Cell-Intrinsic Role of PD-L1 in Regulation of Vulnerability to Ferroptosis

Yang-Ying-Fan Feng,Yi-Cun Li, Hai-Ming Liu, Rui Xu,Yu-Tong Liu,Wei Zhang,Hong-Yu Yang,Gang Chen

CELL REPORTS(2024)

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Key words
PD-L1,genome-wide CRISPR synthetic lethality screen,ferroptosis,redox homeostasis,SOD2,reactive oxygen species,ROS,immunotherapy,cell death,intrinsic function of PD-L1
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