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CRISPR/Cas9-mediated Genome Editing of the Thymidine Kinase Gene in a Clinical HSV-1 Isolate Identifies F289S As Novel Acyclovir-Resistant Mutation

Shuxuan Zheng, Georges M. G. M. Verjans,Anouk Evers, Ellen van den Wittenboer, Jeroen H. T. Tjhie,Robert Snoeck,Emmanuel J. H. J. Wiertz,Graciela Andrei,Jeroen J. A. van Kampen,Robert Jan Lebbink

ANTIVIRAL RESEARCH（2024）

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Key words
Herpes simplex virus 1,Recurrent herpetic eye disease,CRISPR/Cas9,Thymidine kinase,Acyclovir resistance
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