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Preclinical Proof of Principle for Orally Delivered Th17 Antagonist Miniproteins

Stephanie Berger,Franziska Seeger,Ta-Yi Yu, Merve Aydin,Huilin Yang,Daniel Rosenblum,Laure Guenin-Mace,Caleb Glassman, Lauren Arguinchona, Catherine Sniezek,Alyssa Blackstone,Lauren Carter,Rashmi Ravichandran,Maggie Ahlrichs,Michael Murphy,Ingrid Swanson Pultz,Alex Kang,Asim K. Bera,Lance Stewart,K. Christopher Garcia,Shruti Naik,Jamie B. Spangler,Florian Beigel,Matthias Siebeck,Roswitha Gropp,David Baker

CELL（2024）

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Key words
IL-23R,IL-17,Th17,autoinflammation,inflammatory bowel disease,protein engineering,computational protein design,oral biologics
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