Arsenite Provides a Selective Signal That Coordinates Arsenate Uptake and Detoxification Through the Regulation of PHR1 Stability in Arabidopsis

(Molecular Plant 14, 1489–1507; September 6, 2021) In the “Accession numbers” section in the originally published version of our manuscript, we mistakenly listed At5g44570 as the Arabidopsis Genome Initiative locus identifier for the gene CAD1. The correct locus identifier is At5g44070. We apologize for any confusion this has caused. Arsenite provides a selective signal that coordinates arsenate uptake and detoxification through the regulation of PHR1 stability in ArabidopsisNavarro et al.Molecular PlantMay 25, 2021In BriefPhosphate and the chemically similar toxic element arsenate enter plant cells through PHT1 high-affinity phosphate transporters. Here, we uncover a mechanism that coordinates arsenate uptake with the plant’s detoxification capacity. We demonstrate that arsenite is a signal that controls PHT1 expression through the degradation of its activator, PHR1. We identify ASK18 and PHIF1 as ubiquitination system components that control the stability of PHR1 in response to arsenate. Full-Text PDF Open Archive