Relationship Between the Volume of Benzyl Substituent in Isatin-3-acylhydrazones and Their Antimicrobial Activity

Water-soluble ammonium salts were prepared by the reaction of new sterically hindered isatin derivatives with analogues of Girard's reagents. The resulting isatin-3-hydrazones exhibit high antimicrobial and antiaggregation activity with low hemotoxicity. The dependence of physiological activity on the volume of the benzyl substituent was established.