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Discovery of Novel Pyrrolo[2,1-C][1,4]benzodiazepine-3,11-dione (PBD) Derivatives As Selective HDAC6 Inhibitors for the Efficient Treatment of Idiopathic Pulmonary Fibrosis (IPF) in Vitro and in Vivo

Yanchun Li,Huali Yang, Xiangling Zhao, Xianchen Zhao,Jishun Quan, Lei Wang,Enlong Ma,Chao Ma

European Journal of Medicinal Chemistry（2024）

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Key words
Idiopathic pulmonary fibrosis (IPF),HDAC6,Selectivity,Pharmacological mechanism,Mouse model
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