Waking the Sleeping Giant: Single-stranded DNA Binds Schlafen 11 to Initiate Innate Immune Responses

Stephanie A Ragland,Jonathan C KaganTop Scholar

Science immunology（2024）SCI 1区

Division of Gastroenterology

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Abstract

Single-stranded DNA containing CGT/A motifs binds to the helicase domain of Schlafen 11 (SLFN11) to initiate cell death and cytokine production via SLFN11 ribonuclease activity (see related Research Article by Zhang et al. ).

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【要点】：本文发现单链DNA中含有的CGT/A基序能与Schlafen 11蛋白的解旋酶域结合，启动细胞死亡和细胞因子产生，从而激活天然免疫反应。

【方法】：通过分析单链DNA与Schlafen 11蛋白的相互作用及其生物学效应。

【实验】：实验具体操作未详述，但结果表明单链DNA激活SLFN11的核糖核酸酶活性，相关数据集未提及。