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Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and Β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases

Laura Carzaniga,Ian D. Linney,Andrea Rizzi,Wolfgang Schmidt, Christopher K. Knight,Valentina Mileo,Francesco Amadei,Fiorella Pastore,Daniela Miglietta,Nicola Cesari,Benedetta Riccardi,Roberta Mazzucato,Eleonora Ghidini,Wesley P. Blackaby,Riccardo Patacchini,Loredana Battipaglia,Gino Villetti,Paola Puccini,Silvia Catinella,Maurizio Civelli,Fabio Rancati

JOURNAL OF MEDICINAL CHEMISTRY（2024）

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