Long Term Cardiovascular Adverse Outcomes in Testicular Cancer Survivors: Real-world U.S. Population-Based Study.

5042 Background: The focus of Testicular Cancer (TC) has shifted towards survivorship due to the high cure rates. With the increase in TC survivors population, long-term cardiovascular disease (CVD) have been suggested to be strongly linked with earlier treatment for TC by various hospital based small studies. As it is crucial to investigate this relationship at a population level to develop early prevention strategies to improve TC survivors' overall quality of life (QoL), we analyzed the U.S. The Behavioral Risk Factor Surveillance System (BRFSS) to describe the long-term outcomes of TC survivors in a real-world random population sample. Methods: Using BRFSS cycles between 2014 and 2022, we pulled all patients who reported having a history of TC and compared them to the rest of the men's population sample who had no history of cancer diagnosis. Using national complex weights, we estimated each group outcomes proportions. Further, we evaluated several complex-weighted logistic regression models adjusted for different covariates to describe the association of high blood pressure, high cholesterol, diabetes, BMI of >25, angina, myocardial infarction (MI), and coronary heart disease (CHD). Results: Out of 3,077,806 participants, we identified 308 with a history of TC and 1,169,061 men with no history of cancer. After calculating descriptive demographics, our modeling analysis showed a consistent significant association in reporting history of Angina (OR range from 3.84 to 4.27), CHD or MI (OR range from 2.92 to 3.14). see table. Conclusions: Real-world data indicate alarming results of high prevalence CVD in TC survivors; our results confirm previously reported results from hospital-based cohorts. Our findings support immediate actions to develop and implement preventative strategies in TC survivors. [Table: see text]