Abstract 16394: Increasing Prevalence of Cardiovascular Comorbidities among Patients with Primary Biliary Cirrhosis: 2012-2020

Background: Primary Biliary Cirrhosis (PBC) is an autoimmune cholestatic liver disease characterized by progressive damage to the small bile ducts within the liver. PBC is a chronic inflammatory condition frequently associated with cardiac complications in practice, including hyperlipidemia, cardiac arrythmias, and cardiomyopathy. However, data regarding the cardiovascular disease trends and complications in patients with PBC is limited. Aims: To demonstrate the trends of cardiac complications including atrial fibrillation (AF), congestive heart failure (CHF), cardiac arrythmias, myocardial infarction (MI), coronary artery disease (CAD), and valvular disorders in patients with PBC. Methods: A retrospective cohort study using The National Inpatient Database was used to identify patients with PBC from 2012 to 2020. Results: A total of 22,136 patients inpatients with PBC were identified. Prevalence increased from 2,374 in 2012 (mean [SD] age 63.9 [14.2] years; 85.3% female) to 2,470 in 2020 (mean [SD] age 65.3 [13.9] years; 84.0% female). There was a statistically significant marked increase in MI (4.6% to 8.1%; P<0.001), CHF (14.2% to 21.6%; P<0.001), CAD (14.9% to 17.3%; P<0.001), and AF (12.3% to 16.2%; P<0.001) from 2012 to 2020. There was no significant increase in valvular disorders (8.2% to 9.3%; P=.286) and a significant decrease in cardiac arrythmias (24.2% to 23.4%; P=0.011) found from 2012 to 2020. Conclusion: In an inpatient population with PBC, with there was a significant uptrend in MI, AF, CAD, and CHF between 2012 to 2020. There was no change found in valvular disorders and a downtrend in cardiac arrythmias over the same time frame. Further data assessing the cardiovascular outcomes in PBC and its etiology are needed to optimize strategies for long term management of these patients from a cardiovascular standpoint.