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Risk of Recurrent Venous Thromboembolism and Major Bleeding According to Risk Factor Profiles in Asian Patients: a Subgroup Analysis EINSTEIN-Extension and EINSTEIN-CHOICE

THROMBOSIS JOURNAL(2024)

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摘要
Risks of recurrence and major bleeding with extended anticoagulation in Asian patients with venous thromboembolism (VTE) are similar to those in non-Asian patients but risks according to baseline risk factor profiles is not well documented. Subgroup analysis of two randomized trials, which compared once-daily rivaroxaban (20 mg or 10 mg) with placebo or aspirin (100 mg) for extended treatment in Asian patients with VTE who had completed 6–12 months of anticoagulation. Index events were classified as unprovoked, provoked by major persistent risk factors, minor persistent risk factors, minor transient risk factors, or major transient risk factors. One-year cumulative risks of recurrent VTE were calculated for these risk factor profiles. 367 patients received rivaroxaban, 159 aspirin, and 48 placebo. For patients with unprovoked VTE, one-year cumulative incidences of recurrence in the 202 patients given rivaroxaban, the 89 given aspirin and the 28 given placebo were 1.6
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关键词
Aspirin,Rivaroxaban,Venous thromboembolism,Bleeding,Anticoagulation
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