Ultrasound-derived Rates of Muscle Wasting in the Intensive Care Unit and in the Post-Intensive Care Ward for Patients with Critical Illness: Post Hoc Analysis of an International, Multicentre Randomised Controlled Trial of Early Rehabilitation

Background and aimsMuscle wasting results in weakness for patients with critical illness. We aim to explore ultrasound-derived rates of change in skeletal muscle in the intensive care unit (ICU) and following discharge to the post-ICU ward.DesignPost hoc analysis of a multicentre randomised controlled trial of functional–electrical stimulated cycling, recumbent cycling, and usual care delivered in intensive care.MethodParticipants underwent ultrasound assessment of rectus femoris at ICU admission, weekly in the ICU, upon awakening, ICU discharge, and hospital discharge. The primary outcome was rate of change in rectus femoris cross-sectional area (ΔRFCSA) in mm2/day in the ICU (enrolment to ICU discharge) and in the post-ICU ward (ICU discharge to hospital discharge). Secondary outcomes included rate of change in echo intensity (ΔEI), standard deviation of echo intensity (ΔEISD), and the intervention effect on ultrasound measures. Echo intensity is a quantitative assessment of muscle quality. Elevated echo intensity may indicate fluid infiltration, adipose tissue, and reduced muscle quality.Results154 participants were included (mean age: 58 ± 15 years, 34% female). Rectus femoris cross-sectional area declined in the ICU (−4 mm2/day [95% confidence interval {CI}: −9 to 1]) and declined further in the ward (−9 mm2/day [95% CI: −14 to −3]) with a mean difference between ICU and ward of −5 mm2/day ([95% CI: −2, to 11]; p = 0.1396). There was a nonsignificant difference in ΔEI between in-ICU and the post-ICU ward of 1.2 ([95% CI: −0.1 to 2.6]; p = 0.0755), a statistically significant difference in ΔEISD between in-ICU and in the post-ICU ward of 1.0 ([95% CI, 0.5 to 1.5]; p = 0.0003), and no difference in rate of change in rectus femoris cross-sectional area between groups in intensive care (p = 0.411) or at hospital discharge (p = 0.1309).ConclusionsMuscle wasting occurs in critical illness throughout the hospital admission. The average rate of loss in muscle cross-sectional area does not slow after ICU discharge, even with active rehabilitation.