Figure 1 from PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis

A,PIGA mutations identified in 19 duodenal adenomas and two duodenal adenoma patient-derived organoid lines. Relative location in comparison with known protein domains is shown. B, The VAF of four types of somatic mutation (exonic − synonymous/missense + indels/nonsense; all other mutations) for all adenomas analyzed from FAP and MAP patients. For each duodenal adenoma sample, all somatic mutations are shown as circles indicating the allelic frequency of the respective mutant alleles. The median VAF per sample is represented with a red bar. The APC VAFs are indicated in blue and PIGA in purple. The total number of somatic mutations in each adenoma sample is displayed in the lower graph.