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    • Abnormal Cerebrovascular Activity, Perfusion, and Glymphatic Clearance in Lewy Body Diseases

    Sephira G Ryman,Andrei A Vakhtin,Andrew R Mayer,Harm Jan van der Horn,Nicholas A Shaff,Stephanie R Nitschke,Kayla R Julio,Rawan M Tarawneh,Gary A Rosenberg,Shanna V Diaz,Sarah E Pirio Richardson,Henry C Lin

    Movement disorders official journal of the Movement Disorder Society（2024）

    Department of Translational Neuroscience | Center for Memory and Aging | Department of Internal Medicine | Nene and Jamie Koch Comprehensive Movement Disorder Center

    Cited 0|Views22
    Abstract
    Cerebrovascular activity is not only crucial to optimal cerebral perfusion, but also plays an important role in the glymphatic clearance of interstitial waste, including α-synuclein. This highlights a need to evaluate how cerebrovascular activity is altered in Lewy body diseases. This review begins by discussing how vascular risk factors and cardiovascular autonomic dysfunction may serve as upstream or direct influences on cerebrovascular activity. We then discuss how patients with Lewy body disease exhibit reduced and delayed cerebrovascular activity, hypoperfusion, and reductions in measures used to capture cerebrospinal fluid flow, suggestive of a reduced capacity for glymphatic clearance. Given the lack of an existing framework, we propose a model by which these processes may foster α-synuclein aggregation and neuroinflammation. Importantly, this review highlights several avenues for future research that may lead to treatments early in the disease course, prior to neurodegeneration. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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    【要点】：本文综述了路易体病中脑血管活动、灌注和淋巴清除的异常，并提出了一个模型来解释这些异常如何促进α-synuclein聚集和神经炎症，强调了未来研究方向以早期治疗疾病。
    

    【方法】：本文通过讨论血管风险因素和心血管自主功能障碍对脑血管活动的影响，以及路易体病患者脑血管活动的减少和延迟，提出了一个疾病机制模型。
    

    【实验】：文章没有详细说明具体的实验过程，但提到了患者表现出减少和延迟的脑血管活动、低灌注以及衡量脑脊液流动的指标减少，这表明了淋巴清除能力下降。这些发现为理解路易体病中α-synuclein的聚集和神经炎症提供了新的视角，并为早期治疗提供了研究方向。