Characterization of Therapeutic Antibody Charge Heterogeneity under Stress Conditions by Microfluidic Capillary Electrophoresis Coupled with Mass Spectrometry

Zhijie Wu,Hongxia Wang,Xueqing Zhao, Chao Gong, Sarah Sidnam, Borja Cantero-Tubilla, Bojana Nedjic-Dugic, Meinuo Li,Jikang Wu, Yue Su,Yu Huang,Haibo Qiu,Ning Li

JOURNAL OF PHARMACEUTICAL SCIENCES（2024）

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关键词

Microfluidic CE-MS,Native intact analysis,Post-translational modifications,Charge variants,Forced degradation

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