Immobilising an Acid-Cleavable Dimeric Phthalocyanine on Gold Nanobipyramids for Intracellular Ph Detection and Photodynamic Elimination of Cancer Cells.
Analyst (London 1877 Online)/Analyst(2024)
摘要
An acetal-linked dimeric phthalocyanine has been synthesised and immobilised on the surface of gold nanobipyramids. The resulting nanocomposite serves as a highly sensitive probe for intracellular pH through its acid-responsive fluorescence and surface-enhanced Raman scattering signals. The phthalocyanine units released in the acidic intracellular environment can also effectively eliminate the cancer cells upon light irradiation, rendering this simple fabricated nanosystem a bimodal and bifunctional theranostic agent.
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