Pulmonary Embolism Increases the Risk of Dyspnea in Pediatric Patients

This study investigated the association between pulmonary embolism (PE) and a subsequent diagnosis of dyspnea in pediatric patients using real world population-based data. We collected de-identified data from TriNetX, a global federated multicenter research database using both UTSouthwestern (UTSW) and Multinational Research Network. Patient ages of 8 to 21 with and without a diagnosis of pulmonary embolism (ICD-10-CM I26) were examined for associations with a new diagnosis of dyspnea (ICD-10-CM R06.0) three or more months after their initial PE diagnosis. The prevalence of PE significantly increased the risk for a new diagnosis of dyspnea after their initial PE diagnosis among all patients in the UTSW Network (risk ratio: 5.00) and Research Network (risk ratio: 6.55). In the Research Network, this risk was significantly higher for females than males (risk ratio: 6.06 Vs. 5.08) (all p<0.001). These findings suggesting that clinicians should consider PE as an independent risk factor for diagnosis of dyspnea in pediatric patients. Supported in part by NHLBI R38HL150214 (PI: Susan Hedayati). This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.