Co-doping of Silicate Bioceramics As a Potential Strategy to Further Enhance Mono-Doping Consequences

Silicate bioceramics have attracted significant attention in medical applications, particularly in hard tissue regeneration, because of their controllable chemical, physical, and biological functionalities, while ensuring biocompatibility. The coordination of silicate bioceramics with mono-dopants has been extensively studied to enhance their osteogenesis, angiogenesis, and antibacterial activity. However, the concept of employing dual or multiple co-doping to further enhance these biomaterials still demands more attention. This review paper originally focuses on the effect of chemical interactions among co-dopants and the principal constituents of the silicates, on the bio-behavior of these bioceramics. Additionally, future prospects of co-doped silicate bioceramics are outlined, including in vivo studies, clinical trials, and potential commercialization.