Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation–Lithiation As a Batch–Flow Process Douglas A. L. Otte , Reed T. Larson , Embarek Alwedi , Travis Armiger , Yonggang Chen , Cheol K. Chung , James Corry , Richard Desmond , Patrick S. Fier , Robert D. Franklin , Erik D. Guetschow , Jackson R. Hall , Holst M. Halsey , Clara Hartmanshenn , Lisa Jellett , Nadine Kuhl , Francois Levesque , Jonathan P. McMullen , Pratiq A. Patel , Mellie June Paulines , Hong Ren , Vailankanni L. Rodrigues , Serge Ruccolo , Lushi Tan , David A. Thaisrivongs , Kai-Jiong Xiao Organic Process Research & Development（2024）
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flow, fluidics, reactive intermediate, CSTR, continuously stirred, PFR, plugflow
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