Network-based Therapeutic Approach for Brain Ischemia: A Broad Therapy for a Specific Patient

Despite years of efforts, translational stroke research has yield to no neuroprotective therapy.Moreover, only singledrug targets remain hitherto being pursued whilst we know that complex diseases are defined by multitarget modules which should be tackled simultaneously (Fig. 1A).Therefore, we here propose a network-based approach for multi-target identification based on human disease genes linked to ischemic stroke, in combination with a network pharmacology, drug repurposing therapeutic approach.Indeed, network pharmacology exploits this From single drug targets to synergistic network pharmacology in ischemic stroke.