Mimicking the Cellular Microenvironment with 3D Hydrogels Enables Target Discovery and Drug Screening
2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)(2023)
Abstract
Drug discovery in cancer typically involves screening cells grown on 2-dimensional, hard plastic dishes; however, since human tissue is neither 2D nor plastic, this environment does not sufficiently emulate human disease. To overcome this limitation, we designed materials (i.e., hydrogels) for 3-dimensional cell culture with the goal of screening cells in an environment that mimics that of native tissue.
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Key words
Drug Screening,Drug Discovery,Matrix Metalloproteinases,Cell Environment,Hodgkin Lymphoma,Brain Cancer,Findings In Cancer,Cell Culture Materials,Cancer Drug Discovery,3-dimensional Culture
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