449. Replication of Hallucination Severity Associating with Reduced Auditory-Language Cortex Connectivity in a Biological Subtype of Psychotic Disorders

Altered properties of auditory and language brain systems may contribute to auditory hallucinations. Previously both common and psychosis subgroup-specific functional connectivity associations were found with hallucination severity in the Bipolar Schizophrenia Network on Intermediate Phenotypes-1 (B-SNIP-1) sample (Okuneye et al., 2020). Subgroups included diagnosis (schizophrenia, schizoaffective, bipolar) or the three B-SNIP Biotype groups based on neurobiological similarity. All patients showed increased connectivity within left auditory regions associated with greater hallucination severity. Interhemispheric auditory cortex connectivity was increased for bipolar subjects and decreased for Biotype 1 in association with greater hallucination severity. We sought to replicate these observations.