Myosin Inhibitor Reverses Hypertrophic Cardiomyopathy in Genotypically Diverse Pediatric Ipsc-Cardiomyocytes to Mirror Variant Correction

Caroline Kinnear,Abdelrahman Said,Guoliang Meng,Yimu Zhao,Erika Y. Wang,Naimeh Rafatian,Neha Parmar, Wei,Filio Billia,Craig A. Simmons,Milica Radisic,James Ellis,Seema Mital

CELL REPORTS MEDICINE（2024）

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Key words

hypertrophic cardiomyopathy,pediatric,induced pluripotent stem cells,cardiomyocytes,CRISPR gene editing,MYH7,MYBPC3,myosin ATPase inhibitor,verapamil,metoprolol

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